Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva
نویسندگان
چکیده
منابع مشابه
Genotypic diversity, a survival strategy for the apicomplexan parasite Theileria parva
The tick-borne protozoan parasite Theileria parva causes East Coast fever (ECF), a severe lymphoproliferative disease of cattle that is a major constraint to the improvement of livestock in eastern, central and southern Africa. Studies in cattle experimentally infected with T. parva have shown that the protective cytotoxic T lymphocyte (CTL) response is tightly focused, with individual animals ...
متن کاملCharacterization of the Theileria parva sporozoite proteome
East Coast fever is a lymphoproliferative disease caused by the tick-borne protozoan parasite Theileria parva. The sporozoite stage of this parasite, harboured and released from the salivary glands of the tick Rhipicephalus appendiculatus during feeding, invades and establishes infection in bovine lymphocytes. Blocking this initial stage of invasion presents a promising vaccine strategy for con...
متن کاملApproaches to vaccination against Theileria parva and Theileria annulata
Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defi...
متن کاملStudies into Location - specific cis - Regulatory Motifs
Bioinformatics) Studies into Location-specific cis-Regulatory Motifs
متن کاملSimulating the evolution of transcriptional regulatory motifs
Transcription factors are proteins that bind DNA for the purpose of regulating the expression of specific genes. The process by which transcription factors identify their binding sites is poorly understood. It is possible to infer the nature of recognition strategies used by transcription factors through an examination of the information content of their associated binding motifs. Unfortunately...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2016
ISSN: 1471-2164
DOI: 10.1186/s12864-016-2444-5